Male pills show early contraceptive pills

According to the preliminary results of a small study, trying to develop a “male pill” safely and effectively is progress.

In a four-week trial of men under 50, hormone-based contraceptive pills were found to be “well tolerated.”

Trialix The American study team said that testosterone levels in participants decreased significantly with the presence of two hormones essential to produce sperm.

Dr. Stephanie Bigg, author of the study, described the results as a “promising breakthrough” in the development of a version of the female contraceptive pill.

But do not get rid of your condoms yet. “It is clear that longer-term studies are needed to address possible side effects,” he added.

She said that attention to male contraceptive pills was strong.

“Women have many options, but many women can not use the hormonal media and other means available to them,” said Big, who heads the Department of Metabolism and Endocrinology at the University of Washington in Seattle.

“Men are increasingly interested in sharing the burden of contraception, in addition to controlling their fertility,” he said.

Testo Drive 365 For the study, the researchers evaluated three doses (100, 200 and 400 milligrams) of a one-time contraceptive model called dimetandrolone undecanoate (DMAU). Two formulas were tested inside the capsules, either powder or castor oil.

DMAU combines the activity of a hormone such as testosterone and progestin. It was developed by the US National Institutes of Health. UU., That financed the study. Canada

It differs from previous attempts to establish male contraceptive pills in several ways. It contains only one substance, instead of two, and has not been associated with any liver toxicity, something that has infected previous male contraception. “Unlike other oral testosterone derivatives, DMAU only needs doses once a day,” he said.

For the study, the researchers randomly divided 100 men into groups of 20 or less. Some men received sugar pills (placebo), while others received a daily oral dose of DMAU in one of three selected doses. DMAU was always consumed with food.

Blood tests revealed that at the highest dose, DMAU inhibited the production of testosterone and other hormones, LH and FSH, which are known to be the key to sperm production.

But none of the participants had complications that could arise from testosterone deficiency, such as mood swings or sexual function disorders.

However, all those who took DMAU were moderately overweight (around 3 to 9 pounds) and had a moderate reduction in “good” (HDL) cholesterol. No serious side effects were reported.

However, the page added that the low sperm production hormones “are not the same” as demonstrated by the actual decrease in the number of sperm.

“We need to have a longer test, three to six months, to show that sperm production decreases with long-term use of DMAU,” he said. He explained that twenty-eight days “is not enough” to answer this question completely.

“But we know from our work, and from the work of many other people in this area, that the degree of” sperm support “to suppress the hormone we observed in this study should be enough to prevent sperm maturation.

“This was a very small study, and there is still a lot of work to be done,” he said. These follow-up efforts have been initiated at the University of Washington and by William Bayoumid Harbor at the University of California.

According to the page, multinational surveys indicate that most men are interested in more options for reversible contraception.

At present, the only reversible male contraceptives are condoms, which is not the most reliable method of contraception, he noted.

The results of the study were presented Sunday in Chicago at a meeting of the Endocrine Society. Research that is issued at meetings is generally considered preliminary until the peer review is published in a medical journal.

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